If you want to be able to handle Excel like letters past 26 like AA then you can use the following function adapted from this question:

<!-- language: lang-js -->
function convertLetterToNumber(str) {
  var out = 0, len = str.length;
  for (pos = 0; pos < len; pos++) {
    out += (str.charCodeAt(pos) - 64) * Math.pow(26, len - pos - 1);
  }
  return out;
}

###Demo in Stack Snippets:

<!-- begin snippet: js hide: true --> <!-- language: lang-js -->
function convertLetterToNumber(str) {
  var out = 0, len = str.length;
  for (pos = 0; pos < len; pos++) {
    out += (str.charCodeAt(pos) - 64) * Math.pow(26, len - pos - 1);
  }
  return out;
}

var testCase = ["A","B","C","Z","AA","AB","BY"];

var converted = testCase.map(function(obj) {
  return {
    letter: obj,
    number: convertLetterToNumber(obj)
  };

});

console.table(converted);
<!-- end snippet -->